The NanoDe delivery technology is a novel non-viral, non-lipid nucleic acid delivery system, that:
- Encapsulates/ delivers oligos, RNA, DNA
- Infiltrates difficult-to-deliver tissues including the CNS (crosses BBB)
- Delivers with great efficiency, thus lowers dosing and improving safety
- Targets cells and tissues via cellular receptor
- Has demonstrated efficacy in multiple animal disease models
- Is expected to be cost effective in scale-up
Overcomes challenges such as
- Sequestration by liver
- Biological barriers
- Degradation by nucleases
- Endosomal trapping